Life with Arachnoiditis: Education, Research, Support & Hope
Arachnoiditis, Epidural Fibrosis, Failed Back Surgery Syndrome & Related Spinal Disorders
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Research - Articles - Clinical Trials

Clinical Trials: Clinical trial sites listed below are currently the three largest sites regarding clinical trials.  All trials performed by branches of government are found at The other two sites have great search engines and registration areas by drug, disease or region. 

Research & Other Articles:

Vitamin C: Past, Present, Future Applications by Thomas Levy, MD. - The American College for Advancement in Medicine This is the ACAM site where they offer video presentations on demand. For this presentation, scroll down to the presentation on Vitamin C by Levy.  This video is critical for anyone asking, "How can intravenous ascorbic acid help?"
Article: Resolution of symptomatic epidural fibrosis following treatment with combined pentoxifylline-tocopherol
Article: Randomized, Placebo-Controlled Trial of Combined Pentoxifylline and Tocopherol for Regression of Superficial Radiation-Induced Fibrosis
U S Food and Drug Administration - The Orphan Drug Act as Amended
Ion Channels for Beginners : The ABC's of Ion Channels - For those wishing to learn more about neural behavior as it may relate to Arachnoiditis. This article will give you a basic understanding of ion channels.
Arachnoiditis; Familial spinal arachnoiditis (subtype); Spinal tuberculous arachnoiditis (subtype) at NIH's Office of Rare Diseases
Burton Report - - Dr. Burton is well respected and has set many guidelines for treatment of Arachnoiditis.
Cathcart Tolerance Article - Article on Vitamin C titration. Includes specific diseases and statistics for different applications. 
Access article from on Fibrolynosis and Scar Tissue: Influence of fibrinolytic factors on scar formation after lumbar discectomy. A magnetic resonance imaging follow-up study with clinical correlation performed 7 years after surgery.
Dullerud R, Graver V, Haakonsen M, Haaland AK, Loeb M, Magnaes B.
Department of Neuroradiology, Ullevaal University Hospital, Oslo, Norway.

STUDY DESIGN: Prospective cohort study. OBJECTIVES: To assess the amount of scar tissue by viewing magnetic resonance images, and to evaluate the correlation between the amount of scar tissue and clinical outcome, surgical technique, and fibrinolytic factors. SUMMARY OF BACKGROUND DATA: The influence of fibrinolytic factors on magnetic resonance images has not been investigated previously. The relation between clinical outcome and findings on magnetic resonance imaging remains uncertain. METHODS: Magnetic resonance imaging at 0.5 Tesla was performed to produce sagittal and axial spin-echo T1-weighted images before and after contrast enhancement on 78 patients 7 years after traditional lumbar discectomy with partial or full laminectomy. Before surgery all patients had been tested for fibrinolytic factors. RESULTS: The overall clinical success rate of the surgery was 73%. No evidence of scar formation was seen in 19 patients, a small amount was seen in 36 patients, a moderate amount in 17 patients, and a large amount was observed in 6 patients. Ten patients who had undergone surgery at two disc levels and 18 who had been treated with full laminectomy exhibited more scar tissue than those patients who had undergone surgery on a single level (P = 0.033) and those who had undergone a partial laminectomy, respectively (P = 0.017). The amount of scar formation also was associated with a poor outcome (P = 0.017) and with low preoperative values of tissue plasminogen activator antigen (P = 0.003) and tissue plasminogen activity (P = 0.048) in samples collected after venous occlusion. The intensity of contrast enhancement, however, was not influenced by these or any other parameters. CONCLUSION: The amount of scar formation after lumbar discectomy seems to be related to the clinical outcome, the size of the surgical exposure, and some fibrinolytic factors.

More information on fibrinolysis: and in the search box enter:  "fibrinolysis and scar tissue"

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Life with Arachnoiditis: Education, Research, Support & Hope
Arachnoiditis, Epidural Fibrosis, Failed Back Surgery Syndrome & Related Spinal Disorders
Copyright & Non Profit Organization status in process
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